anti-inflammatory corticosteroid widely used in the treatment of asthma to combat inflammation .
Budesonide is an anti-inflammatory corticosteroid, widely used in the treatment of asthma to combat inflammation.It has a great anti-inflammatory potency, which together with a fairly high safety profile makes it the most widely used corticosteroid in the world to treat this pathology. and treatment of choice not only in asthma, but also in COPD, and other pathologies where inflammation may exist, such as rhinitis and nasal polyposis .
-Budesonide has unique pharmacological properties, in which a rapid onset of action is combined with a sustained effect. -Low doses of budesonide effectively control inflammation and prevent exacerbations -Temporary increases in doses of budesonide effectively control exacerbations in asthma .
Start of action
The rapid onset of action after a single dose of budesonide was first documented in the 1980s (Ellul-Micallef EA & Johansson SA, 1983 ) and was later confirmed by Engel et al ( 1991 In this double-blind, crossover study in patients with stable asthma (n = 30; mean FEV1 62% of predicted) who normally used inhaled GCS every day without doing so for 8 days prior to the study. Patients received a single dose of placebo or budesonide (1600 μg) and the change in FEV1 was monitored at 9 hours. The increase in FEV1 3 hours after inhalation of budesonide was significantly higher than after placebo, and its effect was maintained for at least 9 hours. Budesonide causes a rapid improvement in FEV1, suggesting that it can be used in the treatment of asthmatic exacerbations.
Patients (n = 12 who were out of control with their current asthma therapy (mean FEV1 <80% of predicted) received 1600 μg and 400 μg of inhaled budesonide and 40 mg of prednisolone , in this double-blind, crossover study. Rapid onset of action of budesonide was comparable to that of prednisolone (the standard corticosteroid in the treatment of acute asthma )
Parts of the inhaler
– Aluminum – Aerosol -Plastic mouthpiece -Mouthpiece cap
1.- If you are using the inhaler for the first time or the inhaler has not been used for a minimum of 2 days, release the puff into the air. 2.- Take the cap off the nozzle and check that it is clean. Shake the inhaler well after each use. 3.- Hold the inhaler up, with your thumb on the base, as indicated in the figure. Place one or two fingers on the top of the metal container. Exhale gently, through your mouth (blow all the air out of the lungs ). Place the mouthpiece inside your mouth , press firmly with your lips (Do not bite) 4-Gently tilt your head backward. Take a long, deep breath through your mouth, together squeeze the metal container only once with your index finger. 5. After taking a deep breath, hold your breath for 10 seconds or as long as you can. Breathe out slowly. 6.If another dose is required, wait at least one minute and repeat from stages 2 to 5. After you finish using the inhaler, place the cap on the mouthpiece.
Do not rush in stages 4 and 5. It is important that you start by breathing in slowly just before releasing the dose. Practice in front of a mirror the first few times. If you see “steam” coming from the top of the inhaler or from your fingers mouth, start over from stage 2. Vapor release indicates failure of inhaler use mode.
Children: Parents should assist children if they need help in the correct use of the inhaler.
Clean the inhaler at least once a week. 1. Remove the aluminum- spray bottle from the inhaler’s plastic mouthpiece. Remove the cap from the mouthpiece. 2. Wash the plastic mouthpiece and mouthpiece cap with tap water. 3. Shake well to remove excess water and allow to dry. Avoid using heat. 4. Correctly place the aluminum aerosol bottle and the mouthpiece cap on the plastic container of the inhaler.