The Bupropion is a known antidepressant drug type, although only in its application for depression is more common and distinctive for its effectiveness in treating addiction snuff. In this sense, it is a treatment that does not include nicotine and that is recommended together with some type of therapy or psychological treatment .

The bupropion is a specific inhibitor of the reuptake of dopamine and noradrenaline , which works by increasing the levels of these neurotransmitters in the brain. Compared with other drugs in the group of antidepressants, bupropion has the advantage of not causing sexual dysfunctions, although on the other hand its effectiveness alone seems less compared to other drugs on the market.


Bupropion comes as sustained-release or extended-release (long-acting) tablets and tablets to take by mouth. Wellbutrin regular tablet is usually taken three times a day, with doses at least 6 hours apart or four times a day, with doses at least 4 hours apart. Wellbutrin sustained-release tablet is usually taken twice a day, doses at least 8 hours apart. Aplenzin , Wellbutrin extended-release tablet is usually taken once a day in the morning; Extended-release tablet doses should be taken at least 24 hours apart. When he bupropion Used to treat temporary affective disorder, it is usually taken once a day in the morning starting in early fall, continuing through winter, and stopping in early spring. Sometimes a lower dose of bupropion is taken for 2 weeks before you stop taking the medicine. Take bupropion with food, if the medicine upsets your stomach. If you have trouble falling asleep or staying asleep, don’t take bupropion too close to bedtime. Take bupropion at about the same time every day. Carefully follow the directions on your prescription label and ask your doctor or pharmacist to explain any parts you do not understand. Take bupropion exactly as directed. Do not take more or less of the medicine or take it more often than your doctor’s prescription says.

Swallow the sustained-release tablets and extended-release tablets whole; do not split, chew, or crush them.

Your doctor may tell you to start with a low dose of bupropion and gradually increase your dose.

It may take 4 weeks or more before you feel the full benefit of bupropion . Keep taking bupropion even if you feel fine. Don’t stop taking bupropion without talking to your doctor. Your doctor may gradually decrease your dose.


  • Tell your doctor or pharmacist if you are allergic to bupropion , any other medications, or any of the ingredients in bupropion tablets . Ask your pharmacist or check the Medication Guide for a list of ingredients.
  • Tell your doctor if you take a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate) or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor may tell you not to take bupropion .
  • Do not take more than one product that contains bupropion at a time. You may receive too much medicine and experience severe side effects.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amantadine ; beta blockers such as atenolol , labetalol , metoprolol , Toprol , nadolol, and propranolol ; cimetidine ; clopidogrel ; cyclophosphamide , efavirenz , insulin, or oral diabetes medications; medicines for irregular heartbeat such as flecainide andpropafenone ; medications for mental illness such as haloperidol , risperidone, and thioridazine ; seizure medications such as carbamazepine , phenobarbital, and phentoin]]; levodopa ; lopinavir and ritonavir ; nelfinavir ; nicotine patch; oral steroids such as dexamethasone , methylprednisolone, and prednisone ; orphenadrine ; other antidepressants like citalopram , desipramine , fluoxetine , fluvoxamine, imipramine , nortriptyline , paroxetine, and sertraline ; ritonavir ; sedatives ; Tamoxifen sleeping pills ; theophylline ; thiotepa and ticlopidine . Your doctor may need to change the doses of your medications or monitor you closely for side effects.
  • Tell your doctor if you have or have ever had seizures, anorexia nervosa (an eating disorder), or bulimia (an eating disorder). Also tell your doctor if you drink large amounts of alcohol but expect to stop suddenly or take sedatives but expect to stop suddenly. Your doctor may tell you not to take bupropion .
  • Tell your doctor if you drink large amounts of alcohol, use street drugs or abuse prescription drugs, or have ever had a heart attack; a head injury; a tumor in the brain or spine; arterial hypertension; diabetes or liver, kidney, or heart disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking bupropion , call your doctor.
  • You should know that bupropion can make you drowsy. Do not drive a car or operate machinery until you know how this medicine affects you.
  • Consult your doctor about the safe use of alcoholic beverages while taking bupropion . Alcohol can make the side effects of bupropion worse .
  • You should know that bupropion can cause an increase in your blood pressure. Your doctor may check your blood pressure before starting treatment and regularly while taking this medicine, especially if you are also using nicotine replacement therapy.
  • You should also know that bupropion can cause angle-closure glaucoma (a condition where fluid is suddenly blocked and cannot flow out of the eye causing a rapid and severe increase in eye pressure that can lead to vision loss. ). Talk to your doctor about an eye exam before you start taking this medicine. If you have nausea, eye pain, vision changes, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.
  • You should know that some people have reported symptoms such as changes in behavior, hostility, agitation, depression, and suicidal thoughts (thinking about harming or committing suicide or planning or trying to do so) while taking bupropion to stop smoking. The role bupropion plays in causing these mood swings is unclear as people who quit smoking with or without a drug may experience changes in their mental health due to nicotine withdrawal. However, some of these symptoms occurred in people who took bupropion and continued to smoke. Some people had these symptoms when they started taking bupropion.and others developed them after several weeks of treatment or after stopping bupropion . These symptoms have occurred in people without a history of mental illness and have been worse in people who have already had mental illness. Tell your doctor if you have or have ever had depression, bipolar disorder (mood that changes from depressed to abnormally excited), schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions ) or other mental illnesses. If you experience any of the following symptoms, stop taking bupropion.and call your doctor immediately: suicidal thoughts or actions; new or worsening depression, anxiety, or panic attacks; agitation; restlessness; angry or violent behavior; act dangerously; mania (frenzy, abnormally excited, or irritated); abnormal thoughts or feelings; hallucinations (seeing things or hearing voices that are not there); feel that people are against you; feeling confused or any other sudden or unusual change in behavior. Make sure your family or caregiver is aware of symptoms that can be serious so they can call your doctor if you are unable to seek treatment on your own. Your doctor will monitor you closely until your symptoms improve.

Side effects

  • drowsiness.
  • anxiety.
  • excitement.
  • Difficulty falling asleep or staying asleep.
  • dry mouth.
  • dizziness
  • headache.
  • nausea.
  • Vomiting
  • stomach ache.
  • uncontrollable shaking of a part of the body.
  • loss of appetite
  • weightloss.
  • Constipation.
  • excessive sweating
  • Ringing in the ears.
  • changes in the sense of taste.
  • frequent urination
  • throat pain.

Side effects can be serious

  • seizures
  • confusion.
  • hallucinations (seeing things or hearing voices that do not exist).
  • irrational fears.
  • muscle or joint pain
  • irregular, fast, or pounding heartbeat.
  • Fever.
  • rash or blisters.
  • itch.
  • urticaria.
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs.
  • hoarseness.
  • difficulty breathing or swallowing
  • chest pain.

Bupropion may cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.


Keep this medicine in its original container, tightly closed and out of the reach of children. Store it at room temperature and away from light, excess heat and humidity (not in the bathroom). It is important to keep all medicines out of the sight and reach of children, because many containers (such as weekly pill boxes, and those containing eye drops, creams, patches, and inhalers) are not leak-proof. young children, who can easily open them. In order to protect them from poisoning, always wear safety caps and immediately place medications in a safe place, one that is up high and out of their sight and reach. Medications that are no longer needed should be disposed of in an appropriate manner to ensure that pets, children and other people cannot consume them. However, you should not flush these medications down the toilet. Instead, the best way to dispose of your medications is through a drug take-back program. Talk to your pharmacist or contact your local garbage / recycling department to learn about drug take-back programs in your community.

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